Endocrine Abstracts

Introduction: The extracellular calcium-sensing receptor (CaSR) is a G-protein coupled receptor (GPCR) that is expressed in the parathyroids and kidneys, where it allows regulation of parathyroid hormone (PTH) secretion and extracellular calcium concentrations. Inactivating heterozyogous CaSR mutations result in familial benign hypocalciuric hypercalcaemia. However, the role of CaSR polymorphisms in controlling serum calcium, PTH and bone mineral density (BMD) remains controve...

Introduction: Pancreatic neuroendocrine tumors (PNET) are rare with an incidence of 3–4/1000,000. These tumors are non functional in 70–80% of the cases. The vast majority of them are differentiated neuroendocrine carcinoma. Distant metastasis detected frequently at the onset of diagnosis. Liver and lymph node metastases are the most frequent localizations. Cerebral, skeletal and pulmonary are not infrequent. Primary and metastatic small cell carcinomas with NE diffe...

Introduction: Plurihormonality of pituitary adenoma can be defined as the ability to express more than one hormone. 1–30% of pituitary adenoma are plurihormonal. We describe a case of plurihormonal adenoma with GH and ACTH secretion and triple immunostaining for GH, ACTH and prolactin.Case report: A 40 years old patient presented with sudden weight gain central obesity, hypertension, menstrual disorders, acne, hirsutism suggesting hypercortisolism. ...

Introduction: Amiodarone-induced thyrotoxicosis (AIT) contributes to increased morbidity and mortality in patients invariably having underlying heart disease. In clinical practice, amiodarone therapy often needs to be restarted. When amiodarone is reintroduced, what happens then?Objective: The aim of study is to evaluate the progression of thyroid function after reinstitution of amiodarone in patients with a previous history of AIT. Secondarily, to deter...

Introduction: Medullary thyroid carcinoma MTC represents 5% of all thyroid cancers. It is familial in 30% of the cases. The most frequent metastatic localizations are lymph nodes, liver, lung and bone. We describe prostatic and vesical localizations of a MTC in a patient with multiple endocrine neoplasia (MEN 2B).Case report: A 44 years old patient with MEN 2B operated in 1989 for MTC, bilateral pheochromocytoma and had a cutanuous neurofibroma. He prese...

Background: Osilodrostat is a potent oral inhibitor of the adrenal enzymes aldosterone synthase and 11b-hydroxylase and decreases glucocorticoid and mineralocorticoid production and secretion. Phase 2 and 3 studies from the osilodrostat clinical trial programme have demonstrated the drug’s efficacy and safety in patients with Cushing’s disease. Osilodrostat received European Marketing Authorization (MA) for the treatment of Cushing’s syndrome (CS) in adults....